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Maternal Health Meta Analyses and Other

Maternal Health Research

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These major studies provide robust evidence on the links between breastfeeding and a range of maternal health outcomes.

An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint

This article explores how immunity depends on the selection and transmission of protective components of the immune system at the species level and a microbe-induced population of RORγ-expressing regulatory T cells (Tregs) is essential in controlling gut inflammation. Researchers uncover a non-genetic, non-epigenetic, non-microbial mode of transmission of their homeostatic setpoint and propose a model based on a double-negative feedback loop, vertically transmitted via the entero-mammary axis.

Ramanan, D., Sefik, E., et al. (2020). An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint. Volume 181, Issue 6. https://doi.org/10.1016/j.cell.2020.04.030

Association of Maternal Lactation with Diabetes and Hypertension 

Researchers studying the long-term benefits of breastfeeding (at least 12 months) found a 30% risk reduction for diabetes and a 13% risk reduction of hypertension for mothers studied. Based on these findings, the authors call for increased education on the benefits of breastfeeding for pregnant women in the prenatal and antenatal periods, including the recommendation of breastfeeding as a preventative measure for diabetes and hypertension, in addition to weight loss, exercise and smoking cessation.

Rameez RM, Sadana D, Kaur S, et al. Association of Maternal Lactation With Diabetes and Hypertension: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(10):e1913401. doi:10.1001/jamanetworkopen.2019.13401

The effect of labor medications on normal newborn behavior in the first hour after birth: A prospective cohort study

Skin-to-skin contact after birth between mother and baby has immediate and long-term advantages. Widström’s 9 Stages of Newborn Behavior offer an opportunity to evaluate a baby in the natural, expected and optimal habitat. Intrapartum drugs, including fentanyl administered via epidural and synthetic oxytocin (synOT), have been studied in relation to neonatal outcomes with conflicting results. This study aims to determine the effects of common intrapartum medications on the instinctive behavior of healthy newborns during the first hour after birth through a prospective cohort study.

Brimdyr et al (2019) The effect of labour medications on normal newborn behaviour in the first hour after birth: prospective cohort study. Early Human Development. Vol 132. Pg 30-36. https://www.sciencedirect.com/science/article/pii/S0378378219300945

You and your baby survey 2018 National Perinatal Epidemiology Unit (NPEU)

This large-population survey from the NPEU the health and wellbeing of women who have recently given birth in England and shows positive upward trends in breastfeeding and delay of introduction of solids. The survey also delves into a variety of topics on maternal health including smoking behaviours around the time of pregnancy, return to work patterns and maternal mental health.

Harrison, S., Alderdice, F., et al. (2018). You and your baby survey 2018 (National Perinatal Epidemiology Unit (NPEU)

Breastfeeding history and risk of stroke among parous postmenopausal women in the Women’s Health Initiative

This US study using data of 80,191 women found that, compared with women who had never breastfed, women who reported ever breastfeeding had a 23% lower risk of stroke. This association appeared stronger with longer breastfeeding duration and among non‐Hispanic white and non‐Hispanic black women.

Jacobson, L, Hade, E, et al, (2018). Breastfeeding History and Risk of Stroke Among Parous Postmenopausal Women in the Women’s Health Initiative, Journal of the American Heart Association, 2018;7:e008739

The Lancet breastfeeding series

This powerful series presents resounding evidence that breastfeeding protects health, saves lives and cuts costs in every country worldwide. It finds that women are not getting the support they need to breastfeed, and that breastfeeding success is the collective responsibility of society. It demonstrates that the Baby Friendly Initiative is highly effective in improving breastfeeding practices, and that increasing breastfeeding worldwide could prevent over 800,000 child deaths every year.

The Lancet: Increasing breastfeeding worldwide could prevent over 800,000 child deaths every year

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